ドラッグデリバリーを目指したハイドロタルサイトの高機能化

概要

論文の詳細を見る
Intercalation on hydrotalcite has been expected to apply for the drug delivery system. Osteoblast was cultivated in the culture solution dispersed hydrotalcite-ATP intercalation compound. The cells expanded in volume after 3 h cultivation. Hydrotalcite was not toxic and a part of it can be incorporated in the osteoblast. Fine size of hydrotalcite crystals is necessary for its endocytosis. Their fine crystals of < 50 nm were obtained in the precipitation from aqueous solution in strong magnetic field of 5 T applied vertically to the gravity. The intercalated drug should be concentrated at the diseased part. Magnetic hydrotalcite can be transferred by an external magnetic field to the part. Hydrotalcite was firmly bonded on the surface of magnetite particles by firing its coated complex at 400°C in nitrogen atmosphere.
社団法人粉体粉末冶金協会の論文
2005-11-15