Changes in Circulating and Testicular Levels of Inhibin A and B During Postnatal Development in Bulls

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概要

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• We investigated testicular and circulating levels of dimeric inhibins in Holstein bulls from the infantile to postpubertal periods (5 to 50 weeks of age) and examined the relationship between the profiles of circulating dimeric inhibins and FSH. Concentrations of total inhibin and inhibin B in the testis were highest at 4 to 5 weeks of age but decreased gradually as the bulls aged. Testicular inhibin A levels showed a gradual decline to a nadir at 15 to 26 weeks of age, but by 39 weeks, they were high again. The contents of total inhibin, inhibin A, and inhibin B per testis generally increased with age. Fractionation of testicular homogenates obtained from 15-week-old bulls by a combination of immunoaffinity chromatography and SDS-PAGE confirmed the presence of two major molecular weight forms (32 and 45 kDa) of dimeric inhibins in the testes. Circulating levels of total inhibin and inhibin A showed a significant increase in bulls at around 10 to 14 weeks of age compared to the levels between 5 and 7 weeks of age but decreased thereafter. However, immunoreactivity for inhibin B was not detected in the peripheral circulation, probably because of low sensitivity of the inhibin B assays. The concentrations of plasma FSH were high at 5 weeks of age but declined to lower levels between 11 and 40 weeks, and then increased from 41 weeks onward. There was no significant correlation between the plasma levels of FSH and inhibin A or total inhibin. The results clearly indicate that the bull testis produces inhibin A and B and secretes at least inhibin A into the circulation during postnatal development. However, the profile of circulating FSH in bulls shows no reciprocal relationship with the inhibin A or total inhibin profile during the postnatal period.

• 日本繁殖生物学会の論文
• 2006-12-01

著者

• Kikuchi Kazuhiro

  東京農工大学 大学院農学府

• Kikuchi Kazuhiro

  Dep. Of Animal Sci. National Inst. Of Agrobiological Sciences

• Ozawa Manabu

  Department Of Animal Science National Institute Of Agrobiological Sciences

• Ozawa Manabu

  Institute Of Agriculture And Forestry University Of Tsukuba

• Kikuchi Kazuhiro

  Department Of Animal Science National Institute Of Agrobiological Sciences

• KANEKO Hiroyuki

  Division of Animal Sciences, National Institute of Agrobiological Sciences

• Kaneko Hiroyuki

  Division Of Animal Sciences National Institute Of Agrobiological Sciences

• KANEKO Hiroyuki

  Reproductive Biology Research Unit, National Institute of Agrobiological Sciences

• KIKUCHI Kazuhiro

  Reproductive Biology Research Unit, National Institute of Agrobiological Sciences

• NOGUCHI Junko

  Reproductive Biology Research Unit, National Institute of Agrobiological Sciences

• OZAWA Manabu

  Reproductive Biology Research Unit, National Institute of Agrobiological Sciences

• Ohnuma Katsuhiko

  Reproductive Biology Research Unit (Kannondai), National Institute of Agrobiological Science

• MATSUZAKI Masatoshi

  Faculty of Agriculture and Life Science, Hirosaki University

• Kaneko H

  Division Of Animal Sciences National Institute Of Agrobiological Sciences

• Noguchi J

  Division Of Animal Sciences National Institute Of Agrobiological Sciences

• Noguchi Junko

  Positron Medical Center Tokyo Metropolitan Institute Of Gerontology

• Noguchi Junko

  Reproductive Biology Research Unit Division Of Animal Sciences National Institute Of Agrobiological

• Matsuzaki Masatoshi

  Faculty Of Agriculture And Life Science Hirosaki University

• OZAWA Manabu

  Reproductive Biology Research Unit (Kannondai), Division of Animal Sciences, National Institute of Agrobiological Sciences

• OHNUMA Katsuhiko

  Reproductive Biology Research Unit (Kannondai), Division of Animal Sciences, National Institute of Agrobiological Sciences

• NOGUCHI Junko

  Reproductive Biology Research Unit (Kannondai), Division of Animal Sciences, National Institute of Agrobiological Sciences

• KANEKO Hiroyuki

  Reproductive Biology Research Unit (Kannondai), National Institute of Agrobiological Science

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