Structure and Hypotensive Effect of Flavonoid Glycosides in Kinkan (Fortunella japonica) Peelings
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概要
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An attempt was made to isolate the hypotensive substances from a hot water extract of kinkan. Eight flavonoid glycosides were isolated by repeated chromatography and by gel filtration after extracting with n-butanol and treating with lead subacetate. Their structures were established to be 6, 8-di-C-glucosylapigenin (1), 3, 6-di-C-glucosylacacetin (2), 2-O-α-L-rhamnosyl-4-O-methylvitexin (3), 2-O-α-L-rhamnosyl-4-O-methylisovitexin (4), 2-O-α-L-rhamnosylvitexin (5), 2-O-α-L-rhamnosylorientin (6), 2-O-α-L-rhamnosyl-4-O-methylorientm (7) and ponicilin (8) by UV. MS, 1H-NMR and 13C-NMR spectroscopy, and by sugar analysis. Each component was intravenously injected in SHR-SP (0.5-1.0mg/100g of body weight), 1, 2, 5 and 6 were found to lower the rat blood pressure. Among these compounds, 2, 3, 4, 6 and 7 were new flavone glycosides.
- 社団法人 日本農芸化学会の論文
著者
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OKAMOTO Kozo
Kinki University School of Medicine
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Iizuka Yoshitomi
Research Institute Of Food Science Kinki University
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MATSUBARA Yoshiharu
Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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Kumamoto Hiroyasu
Department of Applied Chemistry, Kinki University School of Science and Technology
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Yokoi Katsumi
Japan Sangaria beverage Co., Ltd.
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KUMAMOTO Hiroyasu
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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