Enhanced Angiogenesis in bFGF-Containing Scaffold Promoted Viability of Enclosed Hepatocytes and Maintained Hepatospecific Glycogen Storage Capacity

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概要

• 論文の詳細を見る

• We fabricated a scaffold of poly (lactic acid) and acidic gelatin, a sustained-release carrier of basic fibroblast growth factor (bFGF), which is a positive regulator of angiogenesis. After 1 week of implantation into mesentery of rats, blood vessels induced in the bFGF-containing scaffolds were almost double those in the bFGF-free scaffolds. Further, histological examination of hepatocyte-immobilizing scaffolds retrieved after 1 week of implantation into the mesentery of the rats that received a 70% hepatectomy revealed that the bFGF-containing scaffolds were more efficient for immobilized cell survival than the bFGF-free scaffolds. As well, hepatocytes in the bFGF-containing scaffolds kept their hepatospecific glycogen storage capacity.

• 社団法人 化学工学会の論文
• 2005-11-01

著者

• Sakai Shinji

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Kawakami Koei

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Takei Takayuki

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Ijima Hiroyuki

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Takei Takayuki

  Department Of Chemical Engineering Faculty Of Engineering Graduate School Kyushu University

• ONO Tsutomu

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Ijima Hiroyuki

  Department Of Chemical Engineering Faculty Of Engineering Graduate School Kyushu University

• Ono Tsutomu

  Department Of Chemical Engineering Faculty Of Engineering Kyushu University

• Sakai Shinji

  Department Of Chemical Engineering Faculty Of Engineering Kyushu University

• Kawakami Koei

  Department Of Chemical Engineering Faculty Of Engineering Kyushu University

• Ijima Hiroyuki

  Dep. Of Chemical Engineering Fac. Of Engineering Graduate School Kyushu Univ. 744 Motooka Nishi-ku F

• Kawakami Koei

  Department Of Chemical Engineering Graduate School Of Engineering Kyushu University

• Sakai Shinji

  Div. Of Chemical Engineering Dep. Of Materials Engineering Sci. Graduate School Of Engineering Sci. Osaka Univ.

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