ハロゲノフェニルグルコシド類の放射線増感に関する研究--m-ヨ-ドフェニルグルコシドの放射線増感効果に対するラジカル捕捉剤の影響

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Radiosensitization with p-CPG, p-BPG and m-IPG was examined in E. coli B when the bacterial suspension and sensitizers were X-ray irradiated under anaerobic eondition. The radiosensitizing lethal effect iucreased in the order of m-IPG≫p-BPG>p-CFG. To elucidate the molecular mechanism of the radiosensitizing activity of m-IPG, the radiosensitizing lethal effect by addition of the radical scavengerss such as KSCN, HCOONa and N2O and (6-3H)-thymidine incorporation into DNA of E. coli B after irradiation was examined. Only the addition of KSCN enhanced greatly the inhibition effect on DNA synthesis of E. coli B by X-ray irradiation. This effect may be attributed to the reaction of (SCN)-2 with some enzymic protein, but it was inhibited in the coexistence of m-IPG. The addition of low concentration of HCOONa inhibited greatly the radiosensitizing lethal effect and the inhibiting effect of 3H-thymidine incorporation with m-IPG. However, the addition of high concentration of HCOONa raised the level of the inhibiting effect of 3H-thymidine incorporation to that of the case where onｌy m-IPG is added. This may be attributed to I-3 resulting from the chain reaction of m-IPG and ･CO-2. By the addition of only N2O, a great radiosensitizing lethal effect and a large inhibiting effect on DNA synthesis of　E. coli B by X-ray irradiation appeared. However, the latter effect was largely inhibited by the existence of m-IPG.
三重大学農学部の論文