生薬の生物活性成分に関する研究(第1報) : 生薬の抗潰瘍作用

概要

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For screening of antiulcerogenic action of the crude drugs, stress-induced ulcers were produced by water immersion of the restrained rat. Wister rats, weighing about 90 g were used for each dose level. After 18 hr fasting, the test compounds were adminstered orally 30 min before the stress. After restraining the rats for 4 hr, the animals were sacrificed and the stomachs were examined. The degree of the erosions in the glandular stomachs were scored. Out of 85 tested crude drugs, Sophorae Radix, Sophorae subprostratae Radix, Chinae Cortex, Polygalae Radix, Platycodi Radix and Trichosanthes Semen showed strikingly preventive effect. It was suggested that cinchona alkaloids and quinolizidine alkaloids were active principles of Chinae Cortex and Sophorae Radix, respectively.
日本生薬学会の論文
1974-06-20