黄連およびベルベリン型アル力ロイドの生物学的研究(第2報) : 代謝および治療効果

概要

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The authors reported previously that the subacute toxicity of berberine-type alkaloids was low in rats. Berberine and coptisine were active in vitro against staphylococcus as well as sulfamethoxazole, so chemotherapy study was carried out on the extract of Coptis japonica, berberine and coptisine against staphylococcal infection in mice. As a reference, sulfamethoxazole exhibited a curative effect, but the extract, berberine and coptisine were ineffective. The metabolism of berberine in mice, rats and pigs was observed by oral adminstration. The urinary level of the metabolite was relatively low, the amount of berberine in the blood was not detectable in rats and mice. But significant quantities of berberine were found in the feces, so berberine was not readily absorbed from the gastrointestinal tract.
日本生薬学会の論文
1972-06-20