2P1-B11 機械刺激応答を活用した筋細胞マイクロアクチュエータの開発

概要

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Recently, robotic studies based on biological materials have been attracting a lot of attention, because of its intrinsic abilities. Biological materials have some interesting capabilities in such a way that tissues as devices can be self-organized, adaptable, self-repaired, and so on. Such significant abilities are based on cellular behavior that reflects mechanical stimuli during the development of the tissues. Under this circumstance, in this paper, we intend to deal with development of a micro-actuator by exploiting mechanical stimulus response of muscle cells. To do so, we carry out the induction of differentiation into myofilaments from a cultured myoblasts C2C12 under the periodic stretching forces for 70 hours. As a result, interestingly, we found that induction of differentiation into myofilament-like calls are promoted under the mechanical stimulus.
一般社団法人日本機械学会の論文