パフィア(Pfaffia glomerate)の老齢雄ハムスターに対する繁殖機能増強作用

概要

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An aqueous extract from Pfaffia glomerate (Amaranthaceae) of Brazilian origin was studied for its effect on the declined reproductive ability of aged male hamsters after oral administration, by the continuous mating method. When the Pfaffia extract was administered at a dose of 1g/kg, five times a week, the male hamster age-dependent reduction of pregnancy rate in females was delayed and the testis of treated hamster were heavier (127%) than those in controls. The histological observation in testicular tissues revealed that the degeneration and deciduation of spermiogenic cells in pfaffia-treated hamsters were less than in controls. Teratogenicity was not observed in any of the newborn hamsters delivered from the female hamsters which had been mated with pfaffia-treated male hamsters. These results indicate that active principles which delay the reduction of male reproductive ability caused by aging are present in Pfaffia glomerate extract.
日本生薬学会の論文
1999-02-20