ローヤルゼリーの抗アレルギー作用の検討

概要

論文の詳細を見る
We have previously shown using in vitro and in vivo experimental systems that Perilla frutescens leaf extract (PFE) exhibits anti-allergic functions through inhibiting IgE production by way of down-regulating the production of the Th2 cytokines IL-4, IL-5, and IL-10, but not that of the Thl cytokine IFN-γ. Th2 cytokines play important roles in allergic responses. In this study, we have examined whether royal jelly (RJ) exhibits anti-allergic functions similar to those of PFE using an immediate hypersensitivity model, in which BALB/c mice were immunized with ovalbumin (OVA)-Alum. In a manner similar to that observed with PFE, intraperitoneal administration of RJ significantly inhibited both OVA-specific IgGl and IgE production, and IL-4, IL-5, and IL-10 production by spleen cells stimulated with OVA. In contrast to PFE, however, administration of RJ also inhibited IFN-γ production by OVA-stimulated spleen cells, and tended to down-regulate OVA-specific IgG2a production. IL-2 production by OVA-stimulated spleen cells was unaffected by the administration of RJ and there were no significant changes in cytokine production by spleen cells in response to concanavalin A (Con A) among the experimental groups. Similar findings were observed when lymph node cells from OVA-Aluinimmunized mice were stimulated with OVA in the presence of RJ. Furthermore, oral administration of RJ also resulted in a significant inhibition of both OVA-specific IgE and total IgE production. These results suggest that RJ exhibits anti-allergic functions through a different mechanism from that of PFE.
日本生薬学会の論文
2001-08-20

ローヤルゼリーの抗アレルギー作用の検討

スポンサーリンク

概要

著者

関連論文

スポンサーリンク