2A1-J04 細胞ビルドアップ型ウェットナノロボティクスの構築と機能創発 : 流体駆動デバイスの構築及び薬物刺激による駆動性能の影響

概要

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In our research, three dimensionally cardiomyocyte gels were reconstructed by using extracellular matrixes gel, which were matrigel and collagen I. The autonomous beating of the gel was synchronized with contraction of cardiomyocytes in the gel. Its beating frequency was increased with concentration of adrenaline in the culture medium. The modulation of frequency could be used for controlling of pumping application as drug stimulation. Finally, the micropump driven by the circular cardiomyocyte gel was demonstrated. The micropump consisted of two check valves and the cardiomyocyte gel actuator. Although the micropump could not generate enough flow to detection, volume changes of the channel in the micropump sync with autonomous gel beating.
2009-05-25