1A2-E08 磁気アルキメデス効果による3次元組織構築 : 細胞挙動の磁場解析による予測と実験データとの比較(ナノ・マイクロバイオシステム)

概要

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Magneto-Archimedes effect enables label-free cellular manipulation by magnetic force. In the present study, we estimate cell movement using computer simulation and compare with experimental results obtained by image analysis. The magnetic susceptibility of Gd-DTPA was determined using NMR and the force applying on the cell was estimated by magnetic simulation. On the other hand, living cells suspended in culture medium including Gd-DTPA were applied to the magnetic field. As a result, the cells moved to lower area of magnetic flux density and formed an egg-shaped spheroid in the bottom center of the chamber. The estimated moving velocity with the simulation was almost in agreement with the actual one. The results show that the final shape of the aggregated cells can be estimated by the computer simulation.
一般社団法人日本機械学会の論文
2011-05-26