C型慢性肝炎のインターフェロン療法と長期予後

概要

論文の詳細を見る
Ninety-four patients with chronic hepatitis C treated with interferon (IFN) were followed up clinically, histologically, and virologically for more than one year after the completion of treatment. The complete responder group (CR) comprised 34 cases (36.2%) in whom HCV-RNA was cleared from serum at least 6 months after treatment. Twenty-nine of the CRs (85%) showed improvements in histology and alanine aminotransferase (ALT) levels. However, even among the 60 non-complete responders (NCR) in whom serum HCV-RNA was detected after treatment, 10 cases (16.7%) showed normalization of ALT levels. The patients infected with HCV of genotype II showed higher serum HCV-RNA levels than those infected wtih genotypes III and IV. HCV-RNA levels tended to be lower in CRs than in NCRs. Before treatment, 52.9% of CRs were histologically diagnosed as CAH-2A, 2 of whom were diagnosed as cirrhosis. Hepatocellular carcinomas were detected in 3 cases (3.2%) after treatment, two of whom were CRs. These results suggest that improvements in histology and ALT levels could be obtained in CR cases, but that long-term follow-up with imaging and other examination techniques is necessary.
東京女子医科大学の論文
1997-10-25