C型慢性肝炎における肝組織内HCV-RNA量とインターフェロン治療効果について

概要

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Liver tissue and serum samples were obtained from 23 patients with chronic hepatitis C, and HCV-RNA levels of those samples were quantitated using RT-competitive PCR assay. We investigated the correlations between the hepatic HCV-RNA level, HCV genotype, and the effects of interferon (IFN) therapy. Complete responders (CR), in whom HCV-RNA was cleared from serum more than six months after the end of IFN treatment, numbered 11 cases (47.8%). Non responders (NR), in whom serum HCV-RNA was detected after treatment numbered 12 cases (52.2%). Before IFN treatment, there was a strong correlation between hepatic and serum HCV-RNA levels (r=0.72, p<0.0001). The HCV-RNA level in liver tissue was significantly higher, i.e., about 10^3 times, than it was in serum. HCV genotypes II and IV showed higher HCV-RNA levels than genotype III in both liver tissue and serum. HCV-RNA levels in liver tissue tended to be lower in CR than in NR. These observations suggest that the effect of IFN can be adequately predicted by looking at only HCV-RNA level and genotype in serum.
東京女子医科大学の論文
1997-06-25