Electron microscopic observation of human hepatocellular carcinoma. A comparative study of ultrastructures of four different histological patterns (trabecular, compact, pseudoglandular and scirrhous patterns).

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Thirty-three operation specimens of human hepatocellular carcinoma were studied by transmission electron microscopy. Bile canalicular structure and sinusoid were usually seen in all histological patterns except gland-like structures resembling bile ducts.<BR>Numerous microvilli projecting from lateral surface were observed more frequently in the compact pattern than in the trabecular pattern.<BR>Gland-like structures could be classified into two groups. One group had hepatocytic tumor cells surrounding the lumen and resembled a dilated bile canaliculus. Another group was composed of tumor cells resembling those of bile duct epithelium.<BR>The scirrhous pattern possessed bile canalicular structures like other histological patterns and contained abundant collagen fibers with fibroblasts and myofibroblasts in the space of Disse.
社団法人日本肝臓学会の論文