p38のラット腎内局在と高血圧モデルでの変動

概要

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The mitogen-activated protein kinase (MAP kinase) plays an important role in the intrace llular signaling pathway. A new phosphorylation cascade family p38 is activated by physical stimulation, such as osmotic stress and ultraviolet. We studied the influence of blood pressure on p38 in vivo. In immunohistochemistry, p38 was stained at the distal tubule and collecting duct of rat kidney. In order to determine the relationship between p38 and in vivo blood pressure in the kidney, we isolated a cDNA clone of rat p38 by polymerase chain reaction method. In DOCA-salt hypertension model rat, blood pressure increased (+30 mmHg; tail-cuff method) and p38 mRNA increased (1.8-fold, p<.05) compared with control rat. In conclusion, p38 exists in the distal tubule and collecting duct, and p38 may be related to blood pressure at the level of transcription.
東京女子医科大学の論文
1998-04-25