22 Cladosporium sp.の生産するクロロシス誘起物質,Viridominic acid A,B,CおよびIsoviridominic acid A

概要

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We have found that the culture filtrate of a fungus, Cladosporium sp., induced chlorosis of higher plants, and isolated five active principles. One of them was identified as cephalosporin P_1(I), and others were new compounds, viri dominic acid A, B, C and isoviridominic acid A (VA-A, B, C and IsoVA-A). From chemical and spectral data, these compounds were shown to be analogues of (I). Ozonolysis of VA-C triketone(XI), which produced and ene-dione(XII), showed that VA-C has the structure (IV). By the chemical correlation to (IV), the structures of VA-A and IsoVA-A were assigned to (II) and (V), respectively. The structure of VA-B was assigned as (III) by CrO_3 oxidation of methyl ester (XV) and dehydration of dihydro-ol triacetate(XXI). The biological activities of these compounds indicated that the configuration of C-11 functional groups and their presence or not were important to their activities.
天然有機化合物討論会の論文
1972-10-01