Erinacine Q, a New Erinacine from Hericium erinaceum, and its Biosynthetic Route to Erinacine C in the Basidiomycete(Organic Chemistry)

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Erinacines as cyathane-xylosides are known to have potent stimulating activity for nerve-growth-factor synthesis. Our search for new cyathane metabolites from a liquid culture of Hericium erinaceum YB4-6237 resulted in the isolation of a new erinacine named erinacine Q (1). NMR spectrometry and a chemical derivation from erinacine P (2) determined the compound to be a derivative in which the formyl group of erinacine P had been reduced to the hydroxymethyl group. To clarify the biosynthetic relationship between erinacine Q and the others, [1'-^<13>C]erinacine Q ([1'-^<13>C]-1) was chemically derived from [1'-^<13>C]erinacine P ([1'-^<13>C]-2) which had been prepared by feeding [1-^<13>C]-D-glucose to the basidiomycete. The biotransformation of labeled erinacine Q into [1'-^<13>C]erinacine C ([1'-^<13>C]-5) via [1'-^<13>C]erinacine P in this basidiomycete was demonstrated by NMR spectrometry.
社団法人日本農芸化学会の論文
2002-03-23