Carbonate Apatite (CAp)における骨伝導能の基礎的研究

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Carbonate contenting apatite (CAp) has demonstrated the capacity to stimulate the bone, when it is applied during osteo-formation stage. However, in some way this ability to promote the bone growth continues unclear and in attempt to investigate this concern, it could be a theory involving the bone and its external soft tissue when a treatment is carried out. In this study, the granulate CAp was synthesized and added to experimentally animal alveolar mucous, as well as monitored with the objective to identify the characteristics and morphological changes during the organic response. A total of three dogs were selected and two incisions of 5mm were performed on both sides of the upper jaw, the incisions were situated in the alveolar mucous of the molars area. After that, two pockets were created, and a prepared CAp block was placed it in one of them considering this as control; whereas in the experimental pocket the CAp block and PRP were mixed with the intention of harmonized the combination. The sections studied and theirs surrounding zones were extirpated from the three dogs after two, four and eight weeks respectively. The samples were stained with Masson's modified process and observed by light microscope, scanning and transmission electron microscope (SEM, TEM) to realize the HE and kind of dispersion on the obtained region of new bone. The observation of CAp blocks and its surroundings zones by light microscope showed augmentation of granulomatous tissue. Furthermore, all specimens presented increase of apparent osteoblasts and a slightly difference of bone formation were demonstrated. The amounts of new bone in the experimental pockets (CAp plus PRP) were greater than in control pockets (CAp). In addition, the micrographs of SEM and TEM illustrated, that the apparent osteocytes were covered by high density collagen fibers. The studied CAp proved the ability to stimulate the osteoconstruction when it is applied it to the alveolar mucous. Nevertheless, the results obtained when CAp was combined with PRP exhibited a higher capacity to promote the cellular specialization and bone formation.
朝日大学の論文

Carbonate Apatite (CAp)における骨伝導能の基礎的研究

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