Super High-Flux Hemofiltration

概要

論文の詳細を見る
Inflammatory cytokines play an important role in the pathophysiology of sepsis. Conventional continuous renal replacement therapy such as continuous hemofiltration (CHF) or continuous hemodiafiltration (CHDF) has been used in the attempt to remove such mediators. However, previous reports have shown only limited removal of them due to the relatively small pore size and limited sieving coefficient for middle molecular mediators with conventional hemofilters. Super high-flux hemofiltration is a novel hemofiltration modality using super high-flux membrane that is characterized by an increased effective pore size designed to facilitate the elimination of inflammatory mediators. Several experimental and clinical studies showed a favorable increase of sieving coefficient and therefore clearance of inflammatory cytokines with super high-flux hemofiltration. It is still unknown whether super high-flux hemofiltration could provide a clinical impact. Further investigation is needed.
日本アフェレシス学会の論文
2007-10-31