MARS^[○!R] (Molecular Adsorbent Recirculating System)の基礎的側面 : Extracorporeal Albumin Dialysisの観点から(<特集>新しい体外循環治療を学ぶ)

概要

論文の詳細を見る
It is difficult for conventional blood purification therapies to remove low molecular weight albumin-binding toxins (ABT). Previous studies reported that albumin dialysate (AD) was effective for removing ABT. In this paper, we have summarized the basic evaluation of a blood purification system using Extracorporeal Albumin Dialysis (ECAD). ECAD could remove bilirubin using either symmetric or asymmetric high-flux membrane dialyzers. The larger pore size membrane removed a larger amount of bilirubin. In the greater albumin concentration in AD, the removal capacity for bilirubin by AD rose. AD could remove not only bilirubin but also other ABT such as phenols, indoxyl sulfate, and methotrexate. Albumin in AD could be regenerated by using a charcoal and a bilirubin adsorption column. Molecular Adsorption Recycling System (MARS^[○!R]) is the brand name and was categorized into the concept of ECAD. ECAD is defined as extracorporeal therapies using AD and high-flux membrane. The characteristics of ECAD include removal capacity for not only water-soluble substances but also ABT and it acts as a renal replacement therapy. The most important target of ECAD is the recovery of the essential function of albumin as a carrier protein, an antioxidant, and a buffer.
日本アフェレシス学会の論文
2005-10-31