炎症性サイトカインと好中球活性化 : 急性血液浄化法の効果(<特集>多臓器不全とアフェレシス)

概要

論文の詳細を見る
In critical illness settings such as systemic inflammatory response syndrome or sepsis, both inflammatory cytokines and neutrophils have major roles in the pathophysiology. In the last decade, several approaches aimed at attenuating or blocking such activations failed to show a measurable improvement in outcome. Continuous renal replacement therapy was supposed to be useful for non-selective removal of humoral mediators by convective, diffusive and adsorptive clearances. However conventional modalities also failed to achieve effective removal of such mediators. Several new approaches such as high volume hemofiltration or super high flux hemofiltration are now being developed to increase the clearances of mediators. It is still unkown whether these approaches will have an effect on cytokine story and neutrophil activation.
日本アフェレシス学会の論文
2004-02-29