Synthesis of Phloretin 2'-O-β-L-Glycosides and Their Inhibitory Action against Sugar Transport in Rat Small Intestine(Food & Nutrition)
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the inhibitory potency of phloretin 2'-0-β-L-glycodides, phloretin 2'-O-(6-deoxy-β-L-galactoside) (1), -2'-O-(6-deoxy-β-L-galactoside) (2) and -2'-O-β-L-glucoside (3) were synthesized. The appropriate phloracetophenone 4'-O-β-L-glycosides were coupled with p-hydroxybenzaldehyde in aq. alkali to yield the respective chalcone glycosides, which were catalytically hydrogenated to give 1-3. Compounds 1-3 as well as phloretin 2'-O-(6-deoxy-α-L-mannopyranoside) (glycyphyllin) each exhibited dose-dependent inhibition of 3-O-methyl-D-glucose-evoked ΔPD (transmural potential difference), using the everted jejunal segment of rats. A kinetic study revealed that the mode of action of 1-3 was non-conpetitive and that their Ki values were more than 400 times smaller than the Km value, indicating that they possess strong inhibitory potency toward the Na^+ co-transporter.
- 社団法人日本農芸化学会の論文
- 1991-11-23
著者
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Goda Toshinao
School Of Food And Nutritional Sciences University Of Shizuoka
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Takase Sachiko
School Of Food And Nutritional Sciences University Of Shizuoka
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Esaki S
Univ. Shizuoka Shizuoka Jpn
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Sugiyama Naoko
Department of Food Science, School of Food and Nutritional Sciences, University of Shizuoka
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Kamiya Shintaro
Department of Food Science, School of Food and Nutritional Sciences, University of Shizuoka
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Sugiyama N
Tokyo Univ. Fisheries Tokyo Jpn
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Kamiya S
Department Of Food Science School Of Food And Nutritional Sciences University Of Shizuoka
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Kamiya Shintaro
School Of Food And Nutritional Sciences University Of Shizuoka
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ESAKI Sachiko
School of Food and Nutritional Sciences, University of Shizuoka
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SUGIYAMA Naoko
School of Food and Nutritional Sciences, University of Shizuoka
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