Decrease of Lactase Activity in the Small Intestine of Jejunum-Bypassed Rats.

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of jejunum-bypass operation on lactase in rat small intestine was examined. Three groups of four or five rats were designated as jejunum-bypassed, sham-operated and normal rats. All animals including normal rats received by pair-feeding 5% glucose/l% NaCI for 5 days following the operation; thereafter they were fed ad libitum the laboratory chow diet. Three weeks after the jejunal bypass operation, the proximal ileum exhibited a hypera plasia as evidenced by a concomitant increase in mucosal contents of both total proteins and DNA. The specific activity of lactase in this segment was significantly lower in the operated rats than sham-operated controls, whereas the specific activity of sucrase in this segment was significantly elevated. The reduction of lactase activity was also evident in the proximal jejunal segment as well as in the distal jejunum which was deprived of luminal nutrition, suggesting that some hormonal factor (s) might be involved in the decrease of lactase activity in jejunum-bypassed animals. Electroim-munoassay revealed that the amount of immunoreactive lactase also declined in the operated rats relative to the sham-operated controls. Our results thus suggest that lactase activity in residual ileum is not only unable to compensate for the loss of digestive-absorptive surface of jejunum, but lactase activity even decreases following jejunum-bypass operation.

• 財団法人 学会誌刊行センターの論文

著者

• Goda Toshinao

  School Of Food And Nutritional Sciences University Of Shizuoka

• Takase Sachiko

  School Of Food And Nutritional Sciences University Of Shizuoka

• SHINOHARA Hisae

  Department of Education, Miyazaki University

関連論文

• Developmental Induction and Villus-Crypt Distribution of Retinol Esterifying Enzyme Activities in Chick Duodenum
• Possible Role of Fatty Acids in Milk as the Regulator of the Expression of Cytosolic Binding Proteins for Fatty Acids and Vitamin A through PPARα in Developing Rats
• Dietary Sucrose Enhances Intestinal Lactase Gene Expression in Euthyroid Rats
• Synthesis of Phloretin 2'-O-β-L-Glycosides and Their Inhibitory Action against Sugar Transport in Rat Small Intestine(Food & Nutrition)
• A Possible Role of a Nuclear Factor NF-LPH1 in the Regional Expression of Lactase-Phlorizin Hydrolase along the Small Intestine
• Effects of Various Dietary Protein Contents on Vitamin A Status of Rats Exposed to Prolonged Immobilization through Suspension.
• Immunoelectron Microscopic Localization of Sucrase-Isomaltase in Rat Small Intestine.
• Monostearoylglycerol-Starch Complex: Its Digestibility and Effects on Glycemic and Lipogenic Responses.
• Decrease of Lactase Activity in the Small Intestine of Jejunum-Bypassed Rats.

スポンサーリンク