Monostearoylglycerol-Starch Complex: Its Digestibility and Effects on Glycemic and Lipogenic Responses.

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概要

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• We examined whether a modification of a starch into an α-amylase resistant form can lead to a reduction of postprandial glucose and insulin responses, and consequently to a change of lipid metabolism in liver and adipose tissue. For this purpose, a processed starch was prepared using a cornstarch (70% amylose and 30% amylopectin) and monoacylglycerol (monostearate; MS), forming monostearate-starch complex (MS-treated cornstarch). When we determined in vitro hydroly-sis of MS-treated cornstarch using α-amylase and intestinal microvillar α-glucosidases, the glucose production rate of the MS-treated cornstarch was slower than the non-treated cornstarch. Measurement of a trans-mural potential difference (ΔPD) evoked by the MS-treated cornstarch in everted rat jejunum showed that the absorption rate of glucose released from the MS-treated cornstarch was also remarkably slower than that from the non-treated cornstarch. The postprandial plasma insulin re-sponse to the MS-treated cornstarch was reduced, although plasma glu-cose response was unchanged. In a feeding study, two groups of five or six male Wistar-strain rats were fed defined diets containing 61.1% MS-treated cornstarch or 58.2% non-treated cornstarch ad libitum for 14 days. Food intakes during the period were similar between the two groups. Feeding the MS-treated cornstarch resulted in a significantly lower maltase activity in upper jejunum than did the non-treated corn-starch feeding. The activities of lipogenic enzymes-fatty acid synthetase (FAS), malic enzyme (ME), and glucose-6-phosphate dehydrogenase (G-6-PDH)-significantly decreased in epididymal adipose tissue of rats fed the MS-treated cornstarch. In the liver, FAS activity was lower in the MS-treated cornstarch group. The results indicated that MS-treated cornstarch was digested less rapidly, and lowered blood insulin response, consequently leading to a declined lipogenesis of adipose tissue and liver. This study suggests that the rate of intestinal hydrolysis of starch is an important determinant of metabolic responses such as glycemic and lipogenic responses to diets.

• 財団法人 学会誌刊行センターの論文

著者

• Goda Toshinao

  School Of Food And Nutritional Sciences University Of Shizuoka

• Takase Sachiko

  School Of Food And Nutritional Sciences University Of Shizuoka

• TAKASE Sachiko

  School of Food and Nutritional Sciences, The University of Shizuoka

• WATANABE Makoto

  Terumo Co.

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