LDL吸着カラム(LA-15)において新たに示されたフィブリノーゲン吸着特性 : 過去の誤解と最新の知見から(<特集>アフェレシス療法における技術的進歩 : 最近のトピックスから)

概要

論文の詳細を見る
Fibrinogen adsorptive characteristics in a dextran sulfate (DS) adsorber for LDL apheresis have not yet been clarified. In this project, an in vitro study using discarded human blood and a clinical study were carried out. As a result of the in vitro study, a reduction of the fibrinogen concentration was observed through the adsorber due to adsorption of fibrinogen to the DS material. In addition, a higher amount of fibrinogen was observed in the fluid obtained from desorption process by adding a highly concentrated NaCl solution. In the clinical study, a 30% removal rate for fibrinogen was observed during the treatment. As in the in vitro experiment, the concentration of fibrinogen in outlet of the adsorber was lower than that in the inlet. Competitive adsorption between fibrinogen and LDL seemed to have occurred from the data of the study. These results were observed with a high reproducibility, although the mechanism of fibrinogen adsorption in the LDL adsorber has not yet been clarified. In addition, the fact that the amount of adsorption strongly depends on its concentration was elucidated during these studies.
日本アフェレシス学会の論文
2006-05-31