イヌを用いた膵組織片移植における実験的研究 : とくに生着条件の基礎的検討

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We carried out the intrasplenic islet auto-transplantation in dogs, and studied biologically and morphologically about the conditions to adhere further safely and accurately. Five of 20 dogs progressed with normal blood sugar on the 1st month after the transplantation in the transplanted group of extirpated pancreas, and 7 of 10 dogs in the transplanted group of 5% residual pancreas, and 3 of them survived with normal blood sugar for 6 months. In the progressed cases of normal blood sugar, the tolerance capability of sugar was well maintained by iv-G.T.T. inboth groups, but favorable blood sugar level was obtained during the whole times in the transplanted group of 5% residual pancreas comparing with the transplanted group of extirpated pancreas. Moreover, immunoreactive insulin (IRI) followed to the elevation of blood sugar was lack by iv-G.T.T., while its basic level was maintained almost similarly with normal level. On the other hand, amylase level in blood revealed the maximum one on the postoperative 1st day and decreased with time course, and recovered to the normal level on the 1st month, thereafter revealed gradual decreasing tendency. Morphologically, in the extirpated splenic specimens at the 6th month after the transplantation, large type cells being similar with internal secretion cells of pancreas were numerously noted and they were positive with the staining by PAP method. Moreover, external secretion tissue revealed the degeneration from the 3rd month, and tissues being similar with pancreatic lobe were almost not noted at the 6th month. The intrasplenic islet transplantation does not cause the postoperative complication, and when transplanted Langerhans' island is kept the rest in the early stage, its adhering ratio can be also improved. Therefore, this transplantation is considered to be useful as one of the therapeutic methods which supply the lacking symptomof the internal secretion after the extirpation of pancreas.
神戸大学の論文

イヌを用いた膵組織片移植における実験的研究 : とくに生着条件の基礎的検討

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