Molecular Surgery of Plasmid Deoxyribonucleic Acid Using Scanning Tunneling Microscopy with a Double-Helix Periodicity
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概要
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Without the aid of enzymes, we have successfully cut pBluescript II KS(-), a plasmid deoxyribonucleic acid (DNA) molecule adsorbed on Cu(111) surfaces at pitch level resolution using a scanning tunneling microscopy (STM) surface science technique. Manipulation is performed by scanning an STM tip over the DNA molecule with increased tunneling current. The results suggest that manipulation probability is anisotropic to the angle between the direction of the scanning tip and the DNA molecule, showing a characteristic feature of the right-handed helix. The mechanism of the manipulation is discussed.
- 社団法人応用物理学会の論文
- 2000-08-01
著者
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中山 喜萬
阪大工
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TANAKA Hiroyuki
The Institute of Scientific and Industrial Research, Osaka University
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Kawai Tomoji
The Institute Of Science And Industrial Research (isir-sanken) Osaka University
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TANAKA Hideyuki
Advanced Technology Research Laboratories, Matsushita Electric Industrial Co., Ltd.
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NAKAYAMA Yoshitaka
The Institute of Scientific and Industrial Research, Osaka University
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Tanaka Hideyuki
Advanced Technology Research Laboratories Matsushita Electric Industrial Co. Ltd.
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Tanaka Hiroyuki
The Institute Of Science And Industrial Research (isir-sanken) Osaka University:jst Presto
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