新規化合物アミドフルメト製剤によるダニアレルゲン抑制効果の準実地試験による評価

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A semi-practical test was conducted in order to evaluate the suppression effect of a total release aerosol (TRA) containing a newly developed acaricide, amidoflumet, on the house dust mite, Dermatophagoides farinae Hughes. Three pieces of carpet sized 80 × 80 cm with harbored mites were maintained by distinct procedures: (1) TRA treatment with weekly vacuuming (Chemical treatment), (2) weekly vacuuming only without TRA (Control A) and (3) 5 vacuumings a week without TRA (Control B). The number of live mites and the mite allergen levels (Der f I and Der f II) obtained from 25 cm^2 area of the carpets were compared with up to 57 days posttreatment. The number of live mites in the chemical treatment carpet was reduced to 1% of the pretreatment level at day 8 and was maintained at the low level (< 5 living mites/25 cm^2) until day 43. The quantities of Der f I and Der f II in the chemical treatment carpet decreased to 45% and 55% of the pretreatment level, respectively. For the control A carpet, the number of live mites and the allergen levels kept increasing for 57 days, and the number of live mites, Der f I and Der f II at day 57 reached 36, 14 and 25 times more than the day 0 levels, respectively. In the contol B carpet, the numbers of live mite between day8 and day 22 were greater than that of day 0. The mite allergen levels of the control B fluctuated until day 22 and then decreased to 6% (Der f I) or 4% (Der f II)of the day 0 levels. This was due to less absolute weight of the collected dust in the control B. Consequently, a treatment of the amidoflumet TRA combined with weekly vacuum cleaning was considered to be a more effective strategy than frequent cleaning (5 times/week) alone for the house dust mite and mite allergen. It was also suggested that more frequent cleanings with a TRA treatment would enhance the allergen avoidance effect.
日本衛生動物学会の論文
2004-03-15

新規化合物アミドフルメト製剤によるダニアレルゲン抑制効果の準実地試験による評価

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