Hydrolysis of Acyl Derivatives of N^1,N^2-Diarylamidine. I
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概要
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The alkaline hydrolyses of N^1-benzoyl-N^1,N^2-diarylacetamidine (V) and N^1-tosyl-N^1,N^2-diarylacetamidine (IX) were examined. In the hydrolysis of V, hydroxide ion attacked the amide carbonyl carbon to form N^1,N^2-diarylacetamidine and benzoic acid. In the hydrolysis of IX, hydroxide ion attacked the amidine carbon, and elimination of the N-tosylarylamino group and arylimino group proceeded in parallel, with that of the latter predominating. The alcoholysis reaction of V proceeded without any added catalyst, in contrast to the case of 1- (N-benzoylarylamino) -3-arylimino-1-propene. A unique peak corresponding to the loss of 64 mass units (sulfur dioxide) was observed in the mass spectrum of IX.
- 社団法人日本薬学会の論文
- 1983-10-25
著者
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尾能 満智子
東邦大薬
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早川 和秀
School Of Pharmaceutical Sciences Toho University
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尾能 満智子
School Of Pharmaceutical Sciences Toho University
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田中 比奈子
School of Pharmaceutical Science, Toho University
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田村 真造
東邦大学 薬
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田中 比奈子
School Of Pharmaceutical Science Toho University
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