Amidines. VIII. A Kinetic Study of Alcoholysis of N^1-Arenesulfonyl-N^1,N^2-diarylacetamidines

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概要

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• Alcoholysis of N^1-Arenesulfonyl-N^1,N^2-diarylacetamidines (1-30) was studied kinetically. The rate of the reaction between the substrates and ethoxide ion depended on the electron-withdrawing resonance effect of the substituents on both the N^1-aryl and N^2-aryl groups to a similar extent. The rate of the neutral alcoholysis depended on the resonance effect of the N^1-aryl substituent to a larger extent than in the former reaction, and depended hardly at all on the electron-releasing resonance effect of the N^2-aryl substituent, showing that the reaction does not proceed by the solvolysis mechanism.A reaction mechanism is proposed in which the rate-determining attack of the nucleophile is accompanied by the concerted departure of the N-arylarenesulfonamide group.

• 社団法人日本薬学会の論文
• 1991-03-25

著者

• 尾能 満智子

  東邦大薬

• 尾能 満智子

  School Of Pharmaceutical Sciences Toho University

• 等々力 玲子

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School Of Pharmaceutical Sciences Toho University

• 田村 真造

  東邦大学 薬

• 等々力 玲子

  School Of Pharmaceutical Sciences Toho University

• Todoriki R

  Toho Univ. Chiba Jpn

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