Amidines.II. : Preparation of Unsymmetrical N^1,N^2-Disubstituted Amidines

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概要

• 論文の詳細を見る

• Unsymmetrical N^1,N^2-disubstituted amidines were prepared by conventional and newly developed methods. Reaction of N^1-tosyl-N^1,N^2-diarylacetamidines and arylamines gave unsymmetrical acetamidines in the presence of basic catalysts, and N^1-acyl-N^1,N^2-di(p-nitrophenyl)formamidines and arylamines gave unsymmetrical formamidines under neutral conditions. Unsymmetrical amidines exist as tautomeric mixtures in solution owing to proton transfer between the two nitrogen atoms, and it was proved on the basis of proton nuclear magnetic resonance (^1H-NMR) evidence that the tautomer in which the hydrogen is attached to the more basic nitrogen atom is predominant.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 尾能 満智子

  東邦大薬

• 尾能 満智子

  School Of Pharmaceutical Sciences Toho University

• 等々力 玲子

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School Of Pharmaceutical Sciences Toho University

• 田村 真造

  東邦大学 薬

• 等々力 玲子

  School Of Pharmaceutical Sciences Toho University

• Todoriki R

  Toho Univ. Chiba Jpn

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