Amidines. I. Hydrolysis of N^1-Acyl- and N^1-Tosyl-N^1,N^2-diarylamidines
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概要
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In acid hydrolysis of N^1-acyl-N^1,N^2-diarylamidines, a water molecule attacked exclusively the amidine central carbon, and the reaction proceeded in parallel through two patheways. One of them leads to the formation of two N-acylarylamines, and the other leads to the formation of N, N-diacylarylamine and srylamine. Acid hydrolysis of N^1-tosyl-N^1,N^2-diarylamidine was also examined. The results were similar to those of the hydrolysis of N^1-acyl-N^1,N^2-diarylamidines.Alkaline hyrdolysis and alcoholysis of N^1-acyl-N^1,N^2-diarylamidines occurred almost exclusively at the amide carbonyl group to give N^1,N^2-diarylamidines and carboxylic acids or their esters.The effects of structural change and the aryl substituents on the rate and direction of the reaction were examined.
- 社団法人日本薬学会の論文
- 1990-03-25
著者
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尾能 満智子
東邦大薬
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尾能 満智子
School Of Pharmaceutical Sciences Toho University
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田村 眞造
School of Pharmaceutical Sciences, Toho University
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田村 眞造
School Of Pharmaceutical Sciences Toho University
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田村 真造
東邦大学 薬
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