Preparation of 3-Substituted Quinolines. I. Alkylation of Malonaldehyde Dianil Derivatives

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概要

• 論文の詳細を見る

• 2-Substituted 1-arylamino-3-arylimino-1-propenes (III) were prepared by the reaction of N-lithio derivatives of 1-arylamino-3-arylimino-1-propenes (malonaldehyde dianil derivatives) (II) and substituted benzyl bromides. 2-Allyl and 2-(2,4-dinitrophenyl) derivatives of II were prepared by the same method. However, the alkylation failed with less reactive alkyl halides such as ethyl iodide as alkylating agents. Hydrolysis of III afforded α-substituted β-(arylamino) acroleins (IV), which afforded 3-substituted quinolines (V) on heating with aluminium chloride.

• 社団法人日本薬学会の論文
• 1983-12-25

著者

• 尾能 満智子

  東邦大薬

• 尾能 満智子

  School Of Pharmaceutical Sciences Toho University

• 等々力 玲子

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School Of Pharmaceutical Sciences Toho University

• 田村 真造

  東邦大学 薬

• 等々力 玲子

  School Of Pharmaceutical Sciences Toho University

• Todoriki R

  Toho Univ. Chiba Jpn

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