Hydrolysis of Malonaldehyde Dianil and β-Arylaminoacrolein Derivatives

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概要

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• The reversible hydrolysis of β-arylaminoacrolein to form arylamine and malonaldehyde was studied kinetically. The catalytic coefficient of hydronium ions (k^<H+>) and dissociation constant of the conjugate acid of β-arylaminoacrolein (K^<BH+>) were evaluated. Hammett plots for k^<H+> and for K_<BH+> were linear. The values of log k^<H+> and pK^<BH+> were expressed by the equations log k^<H+>=1.38σ-2.81 and pK_<BH+>=-1.20σ+0.90,respectively. The reversible hydrolysis of malonaldehyde dianil to form β-arylaminoacrolein and arylamine was examined in relation to that of β-arylaminoacrolein. The preparation of β-arylaminoacrolein by hydrolysis of malonaldehyde dianil was achieved under weakly acidic conditions.

• 公益社団法人日本薬学会の論文
• 1980-08-25

著者

• 尾能 満智子

  東邦大薬

• 尾能 満智子

  School Of Pharmaceutical Sciences Toho University

• 田村 眞造

  School of Pharmaceutical Sciences, Toho University

• 田村 眞造

  School Of Pharmaceutical Sciences Toho University

• 田村 真造

  東邦大学 薬

• 古山 和美

  School of Pharmaceutical Science, Toho University

• 古山 和美

  School Of Pharmaceutical Science Toho University

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