放射性同位元素による医薬品の分析(第7報) : 家兎におけるエフェドリン代謝産物の分析

概要

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Excretion rate of ephedrine and its metabolites was examined by the tracer technique after oral administration of l-ephedrine [α-^<14>C] in a rabbit. The metabolites in a 24 hours urine were examined by paper chromatography, and by reverse dilution and derivative reverse dilution analyses. The metabolites thereby found were norephedrine (av. 1.3%), p-hydroxyephedrine (0.7%), 1-phenyl-1,2-propanediol (5.7%) and its conjugate (23.4%), 1-hydroxy-1-phenyl-2-propanone (0.8%), benzoic acid (19.1%), p-hydroxybenzoic acid (1.3%), hippuric acid (24.0%) and its conjugate (8.9%), p-hydroxyhippuric acid (8.8%). With the unchanged ephedrine (0.7%), these metabolites explained 94.7% of the radioactivity administered. The present results revealed that the main metabolic route of ephedrine in a rabbit is oxidation of its side chain.
1971-05-25