同位体による薬物代謝の研究(第19報) : 安定同位体標識化合物中に混在する放射性同位体の量について

概要

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Commercial stable isotope labeled compounds may have a high abundance of the corresponding radioisotopes, because of the simultaneous enrichment of the radioisotopes during the process for enrichment of the stable isotopes. The tritium or carbon-14 activity in commercial stable isotope labeled compounds was measured. The tritium activity in benzene-d_6 and the carbon-14 activity in barium carbonate-^<13>C were 42.5-360.4 _pCi/ml benzene and 29.0 _pCi/g carbon, respectively. These activities were extremely low compared with those in human body or daily diet. It is concluded that the radiations from the contaminated radioisotopes in stable isotope labeled drugs can cause no detectable health hazards, during short-term administration of drug to human subjects.
社団法人日本薬学会の論文
1977-07-25