Vitamin K Distribution in Rat Liver and Heart Muscle and Some Metabolic Properties

概要

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Intracellular distribution and some additional studies of metabolic fate of vitamin K homologs were studied by isotopic tracer with tritium or carbon-14 labeled vitamin K homologs, vitamin K_1,K_<2(20)> and K_3,to obtain the information about their site of action in the animal tissue. There are several reports on the intracellular distribution of K_1 but no clear result has been obtained about the incorporation site of vitamin K_1 in the animal cell and no report has been found in the case of K_<2(20)>, which is estimated to be a physiologically active type of K homologs in the animal. In our present experiment, K_1 was found to be concentrated in the mitochondrial fraction after a long period of time and K_<2(20)> was faster incorporated in the liver and heart muscle than K_1 and showed remarkably higher affinity to the mitochondrial fraction. K_3 which is less lipophilic than the other two homologs, was less incorporated into the both tissues and stayed in the supernatant fraction. From these observations, it was revealed that K_1 and K_2 which have a long isoprenoid side chain have a higher mitochondrial affinity like other isoprenoid vitamins and the higher affinity of vitamin K to the mitochondrial fraction suggest the possibility of their function in some regulation process in mitochondria other than blood coagulation protein synthesis.
公益社団法人日本薬学会の論文
1973-09-25