Studies on Phenylalanine Metabolism by Tracer Techniques. IV. Biotransformation of D- and L-Phenylalanine in Man

概要

論文の詳細を見る
A healthy human female was loaded with D- and L-phenylalanine (Phe)-d_5 (8 mg/kg body weight), and free Phe-d_5 and tyrosine (Tyr)-d_4,and protein-bound Phe-d_5 in the plasma were assayed by gas chromatography-mass spectrometry with selected ion monitoring. Free Phe-d_5 appeared more rapidly and abundantly in the plasma and disappeared more slowly from the plasma after loading with the D-isomer than after loading with the L-isomer. The maximum concentrations were 1.5 mg/100 ml plasma at 30 min after loading with the D-isomer, and 0.1 mg/100 ml plasma at 2 hr after loading with the L-isomer. The half-lives were 3.3 and 0.5 hr for the D-isomer and the L-isomer, respectively. After loading with the D-isomer, as after loading with the L-isomer, free Tyr-d_4 and protein-bound Phe-d_5 were found in the plasma.
公益社団法人日本薬学会の論文
1981-02-25