分離分析のための分子ふるいに関する研究(第3報) : Sephadexゲルの膨潤と負め電荷に及ぼすリオトロープ系電解質の影響

概要

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Effect of electrolytes on the swelling and the electrostatic properties of Sephadex gels was examined by measurements of ζ-potential of gel particles, effective diffusion coefficient (D_eff) in xerogels, and water regain (W_r) of the gels which had been swollen with aqueous solution of several potassium salts of lyotropic series. It was revealed that the negative ζ-potential of the gel particles decreased in the order of water>NCS^->Cl^->OAc^->Cit^<3->>SO_4^<2->, according to Hofmeister's lyotropic series of the anions, whereas D_eff values increased in the order of water<NCS^-<C1^-<SO_4^<2->. The values of water regain of the gels decreased distinctly in the presence of high concentrations of sulfate. In the presence of electrolytes, swelling of Sephadex gels of G-series was assumed to be restricted by the accompanying sealing of the negative charge.
公益社団法人日本薬学会の論文
1970-04-25