Effects of the Aqueous Extract of Epimedii Herba on the Induction of Oral Tolerance in Mice
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概要
- 論文の詳細を見る
We investigated the effects of the aqueous extract of Epimedii Herba (AEEH) on the induction of oral tolerance. Oral tolerance was induced in mice by giving an oral administration of 20 mg ovalbumin (OVA) 7d before immunization with the antigen. AEEH at 40mg/kg was given orally daily for 6d from 24h after the feeding of OVA. The results showed that oral administration of OVA greatly suppressed total serum and antigen-specific immunoglobulin (Ig) levels, phagocytic activity and delayed-type hypersensitivity (DTH) reaction to the antigen. The suppression of these immune responses to OVA by the oral antigen was associated with a marked reduction of the production of interferon-γ (IFN-γ) and interleukin-4 (IL-4) from spleen cells. However, AEEH treatment significantly blocked the suppression of total serum and antigen-specific IgG2a antibodies, phagocytic activity and DTH response by the oral OVA. The suppression of IFN-γ production by the oral antigen was also greatly decreased by AEEH treatment. Therefore, AEEH appears to be effective in preventing the induction of oral tolerance to OVA.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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Woo Won-hong
韓国
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Woo Won-hong
Department Of Herbal Resources Wonkwang University
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Lee S‐y
Kt&g Central Research Institute
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Lee S‐w
National Chung Cheng Univ. Chiayi Chn
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Kim J‐h
Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor
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Lee Sung-won
Department Of Herbal Resources Wonkwang University
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MUN Yeun-Ja
Department of Herbal Resources, Wonkwang University
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KIM Joung-Hoon
Department of Herbal Resources, Wonkwang University
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IM Sook-Jung
Professional Graduate School of Oriental Medicine, Wonkwang University
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IM Sook-Jung
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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LEE Seung-Yon
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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Mun Yeun-ja
Department Of Herbal Resources Wonkwang University
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Im Sook-jung
Professional Graduate School Of Oriental Medicine Wonkwang University
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Kim Joung-hoon
Department Of Environmental Toxicology Faculty Of Pharmaceutical Sciences Teikyo University
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