Inhibitory Effect of Miconazole on Melanogenesis(Pharmacology)
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概要
- 論文の詳細を見る
Miconazole (MIC), a regional antifungal agent, has been used worldwide in the treatment of superficial mycosis. However, the effect of MIC on skin pigmentation is not known. In this study, we investigated the inhibitory effect of MIC on melanogenesis in B16 melanoma cells. Tyrosinase activity and melanin content were dose dependently decreased by MIC as compared with untreated cells. The level of tyrosinase protein expression was reduced with treatment MIC. A decrease in cell proliferation was observed in B16 cells treated with MIC 30 μM, indicating that the MIC-induced depigmenting effect was caused by inhibition of melanin synthesis and not by destruction of B16 cells. Furthermore, MIC markedly suppressed O-melanocyte stimulating hormone or forskolin-induced tyrosinase activity in B16 cells. Therefore the depigmenting effect of MIC might be due to the inhibition of tyrosinase activity and tyrosinase expression, which eventually slows melanin biosynthesis. These results indicate that MIC may be a useful inhibitor of melanogenesis in B16 cells and suggest that it may have beneficial effects in the treatment of hyperpigmentation disorders such as ephelis and melasma.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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Woo Won-hong
韓国
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Woo Won-hong
Department Of Herbal Resources Wonkwang University
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Lee S‐y
Kt&g Central Research Institute
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Lee S‐w
National Chung Cheng Univ. Chiayi Chn
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Kim J‐h
Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor
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Lee Sung-won
Department Of Herbal Resources Wonkwang University
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MUN Yeun-Ja
Department of Herbal Resources, Wonkwang University
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JEONG Hyun-Woo
Department of Pathology, College of Oriental Medicine, Dongshin University
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LEE Kwang-Gyu
Department of Pathology, College of Oriental Medicine, Woosuk University
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KIM Joung-Hoon
Department of Herbal Resources, Wonkwang University
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Mun Yeun-ja
Department Of Herbal Resources Wonkwang University
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Kim Joung-hoon
Department Of Environmental Toxicology Faculty Of Pharmaceutical Sciences Teikyo University
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Lee Kwang-gyu
Department Of Pathology College Of Oriental Medicine Woosuk University
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Jeong Hyun-woo
Department Of Pathology College Of Oriental Medicine Dongshin University
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