Mechanism of Antioxidative Activity of Fluvastatin-Determination of the Active Position
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify the mechanism of action for the antioxidative activity of fluvastatin sodium (FLV, (±)-sodium (3RS, 5RS, 6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptanoate) and its derivatives, reaction of the corresponding methyl ester of FLV with di-tert-butyl diperoxyxalate was examined, and the corresponding keto derivative was isolated from the reaction mixture. On the basis of this result, it was concluded that the active site is the allylic carbon conjugated with the indole ring.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
-
NISHI Hiroyuki
Analytical Chemistry Research Department, CMC Research Laboratory, Mitsubishi Tanabe Seiyaku Co., Lt
-
MIURA Yozo
Department of Appleid Chemistry, Faculty of Engineering, Osaka City University
-
NAKAMURA Takashi
Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
KOKUSENYA Yoshio
Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
Miura Y
Department Of Applied Chemistry Faculty Of Engineering Osaka City University
-
Nakamura T
School Of Pharmaceutical Sciences Mukogawa Women's University
-
HIROTA Kenichi
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
-
Hirota Kenichi
Department Of Applied Chemistry Faculty Of Engineering Osaka City University
-
Nakamura T
Department Of Hospital Pharmacy School Of Medicine Kobe University
-
Nishi Hiroyuki
Analytical Chemistry Department Product And Technology Development Laboratory Tanabe Seiyaku Co. Ltd
-
Kokusenya Y
Analytical Chemistry Department Product And Technology Development Laboratory Tanabe Seiyaku Co. Ltd
-
Kokusenya Yoshio
Analytical Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Kokusenya Yoshio
Analytical Chemistry Department, Product and Technology Development Laboratory, Tanabe Seiyaku Co., Ltd.,
関連論文
- Determination of Aluminum in Large Volume Parenteral Drug Products Used in Total Parenteral Nutrition Therapy by ICP-MS with a Dynamic Reaction Cell
- Association of Cumulative Cyclosporine Dose with Its Irreversible Nephrotoxicity in Japanese Patients with Pediatric-Onset Autoimmune Diseases(Biopharmacy)
- The Bitterness Intensity of Clarithromycin Evaluated by a Taste Sensor
- Reversal Effects of Ca2+ Antagonists on Multidrug Resistance via Down-regulation of MDR1 mRNA
- Three-Dimensional, but not Two-Dimensional, Culture Results in Tumor Growth Enhancement after Exposure to Anticancer Drugs
- Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells(Molecular and Cell Biology)
- Effects of Reactive Oxygen Species on Cell Proliferation and Death in HeLa Cells and Its MDR1-Overexpressing Derivative Cell Line
- Effects of carvedilol on MDR1-mediated multidrug resistance : comparison with verapamil
- Effects of St John's Wort and Hypericin on Cytotoxicity of Anticancer Drugs
- Antiproliferative Activity of Rhinacanthus nasutus (L.) KURZ Extracts and the Active Moiety, Rhinacanthin C(Pharmacology)
- MDR1 T-129C Polymorphism can be Predictive of Differentiation, and Thereby Prognosis of Colorectal Adenocarcinomas in Japanese(Biopharmacy)
- MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas
- Intradermal Concentration of Hydroquinone after Application of Hydroquinone Ointments Is Higher than Its Cytotoxic Concentration(Biopharmacy)
- A Multi-institutional Study on Adjuvant Chemotherapy for the Prevention of Post-operative Liver Metastases in Colorectal Cancer Patients : Comparison Between Hepatic Arterial and Portal Adriamycin Plus Oral UFT Administration
- Morphology of the Digestive System in the Wood-Feeding Termite Nasutitermes takasagoensis (Shiraki) [Isoptera : Termitidae](Morphology)
- MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
- MDR1 C3435T Polymorphism Is Predictive of Later Onset of Ulcerative Colitis in Japanese(Biopharmacy)
- Effect of Quinine Solutions on Intracellular Ca^Levels in Neuro-2a Cells : Conventional Physiological Method for the Evaluation of Bitterness(Miscellaneous)
- Reversal Effects of Antifungal Drugs on Multidrug Resistance in MDR1-Overexpressing HeLa Cells
- IL-1β Genotype-Related Effect of Prednisolone on IL-1β Production in Human Peripheral Blood Mononuclear Cells under Acute Inflammation(Pharmacology)
- Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
- Effect of Therapeutic Moderate Hypothermia on Multi-drug Resistance Protein 1-Mediated Transepithelial Transport of Drugs
- 急性炎症下におけるヒト末梢血単核球MDR1の遺伝子型に依存した遺伝子発現量ならびに機能低下
- Comparison of Synthetic DNA Templates with Authentic cDNA Templates in Terms of Quantification by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction(Analytical Biochemistry)
- 電流検出方式DNAチップを用いた複数遺伝子型同時判定法のMDR1遺伝子への応用
- Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects(Biopharmacy)
- Factors Influencing the Prediction of Steady State Concentrations of Digoxin
- P-gp誘導 Caco-2 細胞 : P-gp高感度 Assay System の構築
- Effects of Various Storage Conditions and Alterations of Antioxidant Contents on Chromatic Aberration of Hydroquinone Ointment(Biopharmacy)
- Effect of Serum Triglyceride Concentration on the Fluctuation of Whole Blood Concentration of Cyclosporin A in Patients
- Proapoptotic Effect of a Dietary Supplement : Water Soluble Chitosan Activates Caspase-8 and Modulating Death Receptor Expression
- Generation, Isolation, ESR and 1^HENDOR Spectra, and Magnetic Characterization of N-[(4-Nitrophenyl)thio]-2-t-butyl-1-pyrenylaminyl
- The Combination Effect of L-Arginine and NaCl on Bitterness Suppression of Amino Acid Solutions
- The Effect of Various Substances on the Suppression of the Bitterness of Quinine-Human Gustatory Sensation, Binding, and Taste Sensor Studies
- Antioxidative Activity Estimation of Methanol Extracts of Crude Drugs by Electrochemical Detection-High Performance Liquid Chromatography (ECD-HPLC) and Correlation with 1,1-Diphenyl-2-picrylhydrasyl (DPPH) Radical Scavenging Activities
- Studies on the "Signal" Constituents for the Evaluation of Animal Crude Drugs. III. Nucleic Acid Components
- Mechanism of Antioxidative Activity of Fluvastatin-Determination of the Active Position
- Acteoside as the Analgesic Principle of Cedron (Lippia triphylla), a Peruvian Medicinal Plant
- Neurotropic Components from Star Anise : Illicium verum HOOK. fil.
- A kinetic Study of Protein Binding to Ecabet Sodium Using Ouartz-Crystal Microbalance
- Generation and ESR Spectrum of a Persistent and Oxygen-Insensitive-Free Radical. 2,7-Di-t-butyl-1-pyrenoxy
- Preparation and Isolation of an Exceptionally Persistent Nitrogen-centered Free Radical. N-[(4-Nitrophenyl)thio]-2,7-di-t-butyl-1-pyrenylaminyl
- 2,2'(1,3-Phnylene)bis(4-t-butyl-6-phenylphenylnitrene): An ESR Study of aQuintet Dinitrene Coupled with 1,3-Phenylene
- Synthesis and Characterization of Poly(1,3-phenylene)-Based Polyradical Carrying Cyclic Nitroxides. Observation of Ferromagnetic Interaction
- New Method for Preparation of Isolable N-tert-Alkoxyarylaminyl Radicals
- Generation, ESR Spectra, and Isolation of N-(Arylthio)-4-t-butyl-2,6-diphenylphenylaminyl Radicals^1)
- Synthesis of Six-Arm Star Polymer by Nitroxide-Mediated "Living" Radical Polymerization
- バルプロ酸誘発高アンモニア血症に対するCPS1 4217C>A遺伝子多型の影響
- MDR1 Genotype-Related Pharmacokinetics and Pharmacodynamics
- Studies on "Signal" Constituents for Evaluation of Animal Crude Drugs. IV : Application of DNA analytical technique to quality evaluation of medicines containing animal crude drugs
- ESR studies of nitrogen-centered free radicals 34. Addition of a sulfonamidyl radical to unsaturated aromatic and aliphatic hydrocarbons.
- ESR spectroscopic study of triphenylmethyl-substituted thioaminyl radicals: N-(triphenylmethylthio)alkylaminyls and -arylaminyls.
- Persistent nitrogen-centered free radicals, N-(arylthio)-3,5-di-t-butylphenylaminyls. The reactions with phenols.
- ESR studies of nitrogen-centered free radicals. 36. Electron spin resonance spectra of sulfinamidyl radicals and a comparison of hyperfine splitting constants with sulfenamidyl and sulfonamidyl radicals.
- 17O- and 33S-hyperfine splittings for aromatic RCONSAr radicals. Complete evaluation of ESR parameters.
- An ESR study of N,N-bis(arylthio)aminyls. 33S hyperfine splittings.
- Persistent nitrogen-centered free radicals, N-(arylthio)-3,5-di-t-butylphenylaminyls. Decomposition reactions.
- An ESR study of N-sulfonylaminyls.
- Reaction of a stable free nitrogen-centered radical, 3,4-dihydro-2,4,6-triphenyl-2H-1,2,4,5-tetrazin-1-yl, with organoaluminum compounds.
- An ESR study of N-benzoyl- and N-pivaloyl-N-(arylthio)aminyls).
- N-Sulfonylaminyls. The isolation of dimers and their properties.