The Properties of Water of Crystallization of Sodium Prasterone Sulfate

概要

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The properties of water of crystallization of sodium prasterone sulfate (DHA・SO_3Na・2H_2O) were investigated by thermometric measurements. The anhydrous form (DHA・SO_3Na) was very hygroscopic, and easily transformed to the dihydrate. The dihydrate was in a stable phase under ordinary storage conditions. If the released water molecules were not effectively exhausted in the dehydration process, a liquefaction phenomenon due to the interaction between water molecules and DHA・SO_3Na was observed. The activation energy (ΔE) of the dehydration reaction from the dihydrate to the anhydrous form was determined by an isothermal method and a non-isothermal method (Ozawa method) under a constant water vapor pressure, P_<H_2O>=14.9 mmHg. ΔE obtained by the isothermal method was 31.5 kcal/mol and ΔE obtained by the Ozawa method was 31.3 kcal/mol.
社団法人日本薬学会の論文
1981-05-23