吸湿によるヒドロキシプロピルセルロース含有錠の崩壊延長

概要

論文の詳細を見る
The disintegration time of a tablet using hydroxypropylcellulose (HPC) as a binder increased under the condition of high humidity. The mechanism of the increase of disintegration time was studied. The penetration rate of disintegration medium into the tablet decreased with an increase in moisture content of the tablet. Two reasons for this phenomena were considered. The first is a change in the pore size distribution of the tablet by absorption of moisture. The second is a change of the properties of HPC in the pore of the tablet. From the following two results, the second reason was considered to be main one. 1) The pore size distribution of the tablet was not changed under the condition of high humidity. 2) The disintegration time increased by moisture absorption was decreased reversibly by drying.
社団法人日本薬学会の論文
1984-05-25