シアニダノールの結晶形

概要

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The presence of seven crystal forms of cianidanol (tetrahydrate・I, monohydrate・I, II, anhydrate・I, II, III, IV) was confirmed by X-ray diffractometry, thermal analysis and by the measurement of water content. The effect of temperature and humidity on the transformation among the seven crystals were investigated. Anhydrate・I transformed to monohydrate・I in low humidity of 11-44% of relative humidity (R.H.) and tetrahydrate・I in high humidity above 68% of R.H. at 20℃. Monohydrate・I transformed to anhydrate・II in low humidity under 30% of R.H. and monohydrate・II at 75% of R.H., 40℃. Anhydrate・II, III, IV transformed to tetrahydrate・I at 94% of R.H., 20℃. Monohydrate・II did not transform to any other form at 0-94% R.H., 20℃, it was the most stable form at room temperature. Dissolution profiles of the seven crystals measured in water were almost the same.
公益社団法人日本薬学会の論文
1985-01-25