カプセルからのリファンピシンの溶出におよぼす粒径とステアリン酸マグネシウムの影響

概要

論文の詳細を見る
The effect of magnesium stearate on the dissolution rate of rifampicin from a hard gelatin capsule was studied. The interesting phenomenon that the effect was influenced by the particle size of rifampicin was found. In the case of rifampicin (RFP 1) sieved into 42-80 mesh, magnesium stearate slowed down the dissolution rate of rifampicin. On the other hand, magnesium stearate accelerated the dissolution rate of rifampicin (RFP 3) passed through 200 mesh screen. These phenomena indicate that magnesium stearate is distributed over the surface of rifampicin particles to exhibit two different effects. The first is the inhibitory effect on the penetration of dissolution medium into the rifampicin powder bed. This effect is due to the formation of hydrophobic film of magnesium stearate over the surface of rifampicin particles. The second is the accelerating effect on the release of rifampicin from the powder bed to the dissolution medium. This effect is due to the reduction of cohesive force between rifampicin particles by magnesium stearate. In the case of RFP 1,the first effect appeared more remarkably than the second one because the particles were large and the cohesive force between the particles was weak. On the other hand, the second effect appeared more remarkably for RFP 3 because the particles were small and had strong cohesive force.
社団法人日本薬学会の論文
1980-11-25