Determination of Residual Solvents in Drug Substances by Gas Chromatography with Thermal Desorption Cold Trap Injection
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概要
- 論文の詳細を見る
A simple and reliable method has been developed for the determination of residual solvents in drug substances by gas chromatography with thermal desorption cold trap injection. Residual solvents in a sample were desorbed by heating at a temperature higher than the melting point of the sample, then trapped in a cold trap cooled at -130℃. After the cold trap was heated, solvents were injected into an analytical column. These operations were performed automatically by the control unit of the injector. This method is useful for the determination of residual solvents in drug substances because of its high sensitivity without the interference of drug substances. As an example of the application of the method, residual solvents in five drug substances were determined.
- 公益社団法人日本薬学会の論文
- 1995-11-15
著者
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鈴木 博文
Pharmaceutical Research Center, Kanebo, Ltd.,
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中川 寛
Pharmaceutical Research Center, Kanebo, Ltd.,
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朽木 彰
Pharmaceutical Research Center, Kanebo, Ltd.
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秋本 恒一
Pharmaceutical Research Center, Kanebo, Ltd.
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鈴木 博文
鐘紡(株)薬品研究所
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鈴木 博文
Pharmaceuticals Research Center Kanebo Ltd.
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鈴木 博文
鐘紡(株)薬品開発第二研究所
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中川 寛
Pharmaceuticals Research Center Kanebo Ltd.
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杉本 裕之
Pharmaceuticals Research Center Kanebo Ltd.
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秋本 恒一
Pharmaceuticals Research Center Kanebo Ltd.
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Sugimoto Masayuki
Pharmaceuticals Research Center Kanebo Ltd.
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朽木 彰
Pharmaceuticals Research Center Kanebo Ltd.
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中川 寛
鐘紡株式会社薬品総合研究開発室
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秋本 恒一
Pharmaceuticals Research Center, Kanebo, Ltd.,
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