ニフェジビン錠の光分解におよぼす波長依存性

概要

論文の詳細を見る
Photodegradation of nifedipine tablets was studied. In order to prevent nifedipine from photodegradation by package film, the sample tablets were covered with various transparent polyethylene colored films or opaque gelatin films. They were exposed to a 20-watt fluorescent-lamp, mounted approximately 53 cm above the samples for 10 days or more. Photolysis of nifedipine without film or oovered with transparent polyethylene film containing UV absorber was very rapid. However, the colored or gelatin films could prevent the decomposition of nifedipine a little. Especially the red film, which did not transmit the light below 580 nm, prevented perfectly the decomposition of nifedipine for 28 days. The effect of wavelength of light on the photolysis was examined by using a grating monochrometer. It was found that the nifedipine tablet was sensitive to light over the range of wavelength between 340 nm and 560 nm, especially 420 nm. Relationship between protective effect on photolysis of colored or gelatin films and their transmission curves between 340 nm and 560 nm was discussed.
社団法人日本薬学会の論文
1981-12-25