Studies on the Preparation of Bioactive Lignans by Oxidative Coupling Reaction. VI. Oxidation of Methyl (E)-3-(4,5-Dihydroxy-2-methoxyphenyl)-2-butenoate and Lipid Peroxidation-Inhibitory Effects of the Produced Caffeoquinone
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概要
- 論文の詳細を見る
Oxidation of hydrody-α-methylcinnamate 5 derived from 4-methylesculetin afforded the α-methylcaffeoquinone derivative 7 without formation of the oxidative coupling product. The reaction of the α-methylferulate derivative 13 afforded a complex mixture of products. Thus, the hydroxy-α-methylcinnamates seem not to be suitable substrates for oxidative coupling.Compound 7 was tested for inhibitory effect on lipid peroxidation. It showed more potent activity than idebenone in rat brain homogenate, and was much more potent than (±)-α-tocopherol in rat liver microsomes.
- 公益社団法人日本薬学会の論文
- 1995-09-15
著者
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野老山 喬
Faculty Of Science Osaka City University
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前田 四郎
New Drug Research Laboratories Kanebo Co. Ltd.
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増田 博史
Traditional Chinese Medicine Research Laboratories, Kanebo Co. Ltd.,
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増田 博史
Traditional Chinese Medicine Research Laboratories Kanebo Co. Ltd.
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Maeda S
New Drug Research Laboratories Kanebo Co. Ltd.
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